Dr Marta Narczyk

Research interests

1. Investigations of protein-ligand complexes formation by calorimetry, and UV-Visspectroscopy (absorption, emission, circular dichroism).
2. Protein Crystallography.

Professional experience

2006	Msc. in physics and biophysics, Faculty of Physics, Warsaw University, Warsaw, Poland
2006 - 2011	PhD study, Division of Biophysics, Institute of Experimental Physics, University of Warsaw
2011	Four-month training Institut Ruder Bosković, Zagrzeb, Chorwacja
2011 - 2015	Division of Biophysics, Institute of Experimental Physics, University of Warsaw, lecturer

Selected publications

1. Bertosa, B; Mikleusevic, G; Wielgus-Kutrowska, B; Narczyk, M; Hajnic, M; Asler, IL; Tomic, S; Luic, M; Bzowska, A: Homooligomerization is needed for stability: a molecular modelling and solution study of Escherichia coli purine nucleoside phosphorylase FEBS Journal 2014, 281 (7), 1860-1871
2. Stefanic, Z; Mikleusevic, G; Narczyk, M; Wielgus-Kutrowska, B; Bzowska, A; Luic, M: Still a Long Way to Fully Understanding the Molecular Mechanism of Escherichia coli Purine Nucleoside Phosphorylase Croatica Chemica Acta 2013, 86 (1), 117-127
3. Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state Bioorganic & medicinal chemistry 2012, 20 (22), 6758-6769
4. Stefanic, Z; Narczyk, M; Mikleusevic, G; Wielgus-Kutrowska, B; Bzowska, A; Luic, M New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A FEBS letters 2012, 586 (7), 967-971
5. Mikleusevic, G; Stefanic, Z; Narczyk, M; Wielgus-Kutrowska, B; Bzowska, A; Luic, M Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies Biochimie 2011 93 (9), 1610-1622
6. Chojnowski, G; Breer, K; Narczyk, M; Wielgus-Kutrowska, B; Czapinska, H; Hashimoto, M; Hikishima, S; Yokomatsu,; Bochtler, M; Girstun, A; Staron, K; Bzowska, A 1.45 angstrom resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state Biochemical and biophysical research communications 2010, 391 (1), 703-708
7. Wielgus-Kutrowska B., Narczyk M., Buszko A., Bzowska A. and Clark P. L. Folding and unfolding of a non-fluorescent mutant of green fluorescent protein. J. Phys.: Condens. Matter 19 No 28 (18 July 2007) 285223

Science popularization

1. Physics Summer School and Festival of Science
   1. Biophysical and Physical Laboratory
   2. Protein Crystallography

Participation in research projects

Purine nucleoside phosphorylases (PNP): three-dimensional structure and molecular mechanism of catalysis