Prof. Dr hab. Jan Antosiewicz

Current research interests

• Application and development of stopped-flow, laser flash photolysis, brownian dynamics and molecular dynamics methods to study electrostatic and hydrodynamic effects in kinetics of molecular association and molecular dynamics.

• Investigation of protein-ligand association by stacionary and transient near and far UV CD spectroscopy.

  Past research interests:

• Constant-pH molecular dynamics and molecular electrostatics simulations of proteins and protein-ligand systems.

• Investigation of kinetics of protein-ligand association by Brownian dynamics simulations.

• Investigation of multiple protonation equilibria in proteins using Poisson-Boltzmann model of their aqueous solutions.

• Analysis of macromolecular structures and their dynamics in solution by quantitative electro-optics.

• Investigation of biopolymer dynamics by T-jump spectroscopy.

• Investigation of hydration of biomolecules by ultrasonic velocimetry of their aqueous-alcoholic solutions.

Professional experience

1978 - 1986	Department of Biophysics, Warsaw University, Warsaw, Poland; Research Associate
1986 - 1988	Max Planck Institut für biophysikalische Chemie, Goettingen, Germany; Postdoctoral Research Associate.
1988 - 1992	Department of Biophysics, Warsaw University, Warsaw, Poland; Adjunct.
1992 - 1995	Institute for Molecular Design, University of Houston, Houston, Texas, USA; Postdoctoral Research Associate; and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, USA; Visiting Assistant Research Chemist.
1995 - 2001	Department of Biophysics, Warsaw University, Warsaw, Poland; Adjunct.
2002 -	Department of Biophysics, Warsaw University, Warsaw, Poland; Professor

Publications (2018-2022)

1. Jan M. Antosiewicz and Maciej Długosz, Does Ionic Screening Lower Activation Barriers for Conformational Transitions in Proteins?, J. Phys. Chem. B 2018, 122, 11817-11826, DOI: 10.1021/acs.jpcb.8b07525.
2. Paweł Czajka, Jan M. Antosiewicz, and Maciej Długosz, Effects of Hydrodynamic Interactions on the Near-Surface Diffusion of Spheroidal Molecules, ACS Omega 2019, 4, 17016-17030, DOI: 10.1021/acsomega.9b02618.
3. K. Stachurska, P. Grochowski, and J. M. Antosiewicz, Diffusional Encounter Rate Constants for Xanthone and 2‐Naphthoic cid by Flash Photolysis Experiments and Brownian Dynamics Simulations: Substantial Effects of Polarizability of the Triplet State, J. Phys. Chem. B 2019, 123, 9328-9342, DOI: 10.1021/acs.jpcb.9b07989.
4. Jan M. Antosiewicz and Maciej Długosz, Constant-pH Brownian Dynamics Simulations of a Protein near a Charged Surface, ACS Omega 2020, 5, 30282-30298, DOI: 10.1021/acsomega.0c04817.
5. B. Wielgus-Kutrowska, U. Marcisz and J. M. Antosiewicz, Searching for Hydrodynamic Orienting Effects in the Association of Tri-N-acetylglucosamine with Hen Egg-White Lysozyme, J. Phys. Chem. B, 2021, 125, 10701-10709 DOI: 10.1021/acs.jpcb.1c06762.
6. J. M. Antosiewicz and P. M. Kane, Editorial: Intracellular Molecular Processes Affected by pH , Front. Mol. Biosci., 2022, 9, 891533/1-2 DOI: 10.3389/fmolb.2022.891533.
7. K. Stachurska, U. Marcisz, M. Dlugosz and J. M. Antosiewicz, Circular dichroism spectra of α-chymotrypsin-SDS solutions depend on the procedure of their preparation, ACS Omega 2022, 7, 23782-23789 DOI: 10.1021/acsomega.2c02438.