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Name: Prof.dr hab. Jan Antosiewicz
Address: Department of Biophysics, Institute of Experimental Physics, Warsaw University, ¯wirki i Wigury 93, 02-089 Warsaw, Poland
Phone: +48 22 5540786
E-mail: jantosi@biogeo.uw.edu.pl
Current research interests:
- Application and development of stopped-flow, laser flash photolysis,
brownian dynamics and molecular dynamics methods to study electrostatic
and hydrodynamic effects in kinetics of molecular association and molecular dynamics.
- Constant-pH molecular dynamics and molecular electrostatics simulations of
proteins and protein-ligand systems.
- Analysis of macromolecular structures and
their dynamics in solution by quantitative electro-optics.
- Investigation of
protein-ligand association by stacionary and transient near and far UV CD spectroscopy,
in particular to proteins binding analogs of 5'-end of m-RNA.
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Professional experience:
| 1978 - 1986 |
Department of Biophysics, Warsaw University, Warsaw, Poland; Research Associate. |
| 1986 - 1988 |
Max Planck Institut für biophysikalische Chemie, Goettingen, Germany;
Postdoctoral Research Associate. |
| 1988 - 1992 |
Department of Biophysics, Warsaw University, Warsaw, Poland; Adjunct. |
| 1992 - 1995 |
Institute for Molecular Design, University of Houston, Houston, Texas, USA;
Postdoctoral Research Associate; and Department of Chemistry and Biochemistry,
University of California at San Diego, La Jolla, USA; Visiting Assistant Research Chemist. |
| 1995 - 2001 |
Department of Biophysics, Warsaw University, Warsaw, Poland; Adjunct. |
| 2002 - |
Department of Biophysics, Warsaw University, Warsaw, Poland; Professor. |
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Selected papers 2007-2011:
- E. Blachut-Okrasinska, E. Bojarska, J. Stepinski, and J. M. Antosiewicz,
Kinetics of binding the mRNA cap analogues to the the translation
initiation factor eIF4E under second-order reaction conditions,
Biophys. Chem., 129:289-297 (2007)
- E. Blachut-Okrasinska, and J. M. Antosiewicz,
Brownian dynamics simulations of binding mRNA cap analogues to
eIF4E protein,
J. Phys. Chem. B. 111: 13107-13115 (2007)
- J. M. Antosiewicz,
Protonation free energy levels in complex molecular systems,
Biopolymers 89: 262-269 (2008)
- Z. Pilat, J. M. Antosiewicz, Multiple protonation equilibria in electrostatics of protein-protein binding,
J. Phys. Chem. B, 112: 15074-15085 (2008)
- O. Szklarczyk, J. Zuberek and J. M. Antosiewicz,
Poisson-Boltzmann model analysis of binding mRNA cap analogues to the translation initiation factor
eIF4E,Biophys. Chem., 140:16-23 (2009)
- J. M. Antosiewicz and D. Porschke,
Effects of hydrodynamic coupling on electro-optical transients,
J. Phys. Chem. B, 113:13988-13992 (2009)
- Z. Pilat, J. M. Antosiewicz,
pKas of ionizable groups and energetics of protein
conformational transitions, J. Phys. Chem. B, 114:1393-1406 (2010)
- J. M. Antosiewicz, D. Shugar, Poisson-Boltzmann continuum-solvation model:
Applications to pH-dependent properties of biomolecules,
Mol. BioSyst., 7:2923-2949 (2011)
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| Participation in research projects: |
Studies of the macromolecular structure, dynamics and function in solution
Purine nucleoside phosphorylases (PNP): three-dimensional
structure and molecular mechanism of catalysis
Translation initiation and intracellular transport: biophysics of protein and mRNA interactions
Role of 5' mRNA and 5' U snRNA cap structures in regulation of gene expression
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Research
