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Warsaw University Faculty of Physics
WERSJA POLSKA  Research    People    Education
Name: Prof.dr hab. Jan Antosiewicz
Address: Department of Biophysics, Institute of Experimental Physics, Warsaw University, »wirki i Wigury 93, 02-089 Warsaw, Poland
Phone: +48 22 5540786
E-mail: jantosi@biogeo.uw.edu.pl

Current research interests:

  1. Application and development of stopped-flow, laser flash photolysis, brownian dynamics and molecular dynamics methods to study electrostatic and hydrodynamic effects in kinetics of molecular association and molecular dynamics.
  2. Constant-pH molecular dynamics and molecular electrostatics simulations of proteins and protein-ligand systems.
  3. Analysis of macromolecular structures and their dynamics in solution by quantitative electro-optics.
  4. Investigation of protein-ligand association by stacionary and transient near and far UV CD spectroscopy, in particular to proteins binding analogs of 5'-end of m-RNA.
Professional experience:
1978 - 1986 Department of Biophysics, Warsaw University, Warsaw, Poland; Research Associate.
1986 - 1988 Max Planck Institut für biophysikalische Chemie, Goettingen, Germany; Postdoctoral Research Associate.
1988 - 1992 Department of Biophysics, Warsaw University, Warsaw, Poland; Adjunct.
1992 - 1995 Institute for Molecular Design, University of Houston, Houston, Texas, USA; Postdoctoral Research Associate; and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, USA; Visiting Assistant Research Chemist.
1995 - 2001 Department of Biophysics, Warsaw University, Warsaw, Poland; Adjunct.
2002 - Department of Biophysics, Warsaw University, Warsaw, Poland; Professor.
Publikacje (2011-2015):
  1. J. M. Antosiewicz, D. Shugar, Poisson-Boltzmann continuum-solvation model: Applications to pH-dependent properties of biomolecules, Mol. BioSyst., 7:2923-2949 (2011)
  2. M. Dlugosz, J. M. Antosiewicz, P. Zielinski, J. Trylska, Contributions of Far-Field Hydrodynamic Interactions to the Kinetics of Electrostatically Driven Molecular Association, J. Phys. Chem. B, 116:5437-5447 (2012)
  3. M. Dlugosz, J. M. Antosiewicz, Anisotropic diffusion effects on the barnase-barstar encounter kinetics, J. Chem. Theory Comp., 9:1667-1677 (2013)
  4. M. Dlugosz, J. M. Antosiewicz, Hydrodynanamic effects on the relative rotational velocity of associating proteins, J. Phys. Chem. B, 117:6167-6174 (2013)
  5. Z. Gasik, D. Shugar, J. M. Antosiewicz, Resolving Differences in Substrate Specificities between Human and Parasite Phosphoribosyltransferases via Analysis of Functional Groups of Substrates and Receptors, Current Pharmaceutical Design, 19:4226-4240 (2013)
  6. M. Dlugosz, J. M. Antosiewicz, Evaluation of proteins' rotational diffusion coefficients from simulations of their free Brownian motion in volume-occupied environments, J. Chem. Theory Comp., 10:481-491 (2014)
  7. M. Dlugosz, J. M. Antosiewicz, Transient effects of molecular crowding on translational diffusion of anisotropic molecules, J. Chem. Theory Comp., 10:2583-2590 (2014)
  8. J. Wierzchowski, J. M. Antosiewicz, D. Shugar, 8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research, Molecular BioSystems, 10:2756-2774 (2014)
  9. M. Dlugosz, J. M. Antosiewicz, Toward accurate modeling of hydrodynamic effects on the translational and rotational dynamics of biomolecules in many-body systems, J. Phys. Chem. B, 119:8425-8439 (2015)