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Warsaw University Faculty of Physics
WERSJA POLSKA  Research    People    Education
Name: Dr. hab. Jan Antosiewicz (Professor)
Address: Department of Biophysics, Institute of Experimental Physics, Warsaw University, ¯wirki i Wigury 93, 02-089 Warsaw, Poland
Phone: +48 22 5540786
E-mail: jantosi@biogeo.uw.edu.pl

Current research interests:

  1. Application and development of brownian dynamics methods to study molecular association and dynamics.
  2. Application of stopped-flow methods to study macromolecular dynamics and kinetics of molecular association.
  3. Constant-pH molecular dynamics simulations of proteins and protein-ligand systems.
  4. Investigation of macromolecular structures and dynamics by flash photolysis methods.
  5. Analysis of macromolecular structures and their dynamics in solution by quantitative electro-optics.
Professional experience:
1978 - 1986 Department of Biophysics, Warsaw University, Warsaw, Poland; Research Associate.
1986 - 1988 Max Planck Institut für biophysikalische Chemie, Goettingen, Germany; Postdoctoral Research Associate.
1988 - 1992 Department of Biophysics, Warsaw University, Warsaw, Poland; Adjunct.
1992 - 1995 Institute for Molecular Design, University of Houston, Houston, Texas, USA; Postdoctoral Research Associate; and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, USA; Visiting Assistant Research Chemist.
1995 - 2001 Department of Biophysics, Warsaw University, Warsaw, Poland; Adjunct.
2002 - Department of Biophysics, Warsaw University, Warsaw, Poland; Professor.
Selected papers 2005-2008:
  1. M. Dlugosz, J. M. Antosiewicz, and A. D. Robertson, Constant-pH molecular dynamics study of protonation-structure relationship in a heptapeptide derived from ovomucoid third domain, Phys. Rev. E, 69:021915/1-10 (2004)
  2. D. Porschke and J. M. Antosiewicz, Strong effect of hydrodynamic coupling on the electric dichroism of bent rods, J. Phys. Chem. B, 109:1034-1038 (2005)
  3. M. Dlugosz, A. Bzowska, and J. M. Antosiewicz, Stopped-flow studies of guanine binding by calf spleen purine nucleoside phosphorylase, Biophys. Chem., 115:67-76 (2005)
  4. M. Dlugosz and J. M. Antosiewicz, Effects of solute-solvent proton exchange on polypeptide chain dynamics: A constant-pH molecular dynamics study, J. Phys. Chem. B., 109:13777-13784 (2005)
  5. D. Porschke and J. M. Antosiewicz, Quantitative Molecular Electro-optics: Macromolecular Structures and Their Dynamics in Solution, in: Molecular and Colloidal Electro-optics, Series: Surfactant Science, 134:59-107 S. P. Stoylov and M. V. Stoimenova, Eds., CRC PRESS, Boca Raton, (2006)
  6. E. Blachut-Okrasinska, E. Bojarska, J. Stepinski, and J. M. Antosiewicz, Kinetics of binding the mRNA cap analogues to the the translation initiation factor eIF4E under second-order reaction conditions, Biophys. Chem., 129:289-297 (2007)
  7. E. Blachut-Okrasinska, and J. M. Antosiewicz, Brownian dynamics simulations of binding mRNA cap analogues to eIF4E protein, J. Phys. Chem. B. 111: 13107-13115 (2007)
  8. J. M. Antosiewicz, Protonation free energy levels in complex molecular systems, Biopolymers 89: 262-269 (2008)
Participation in research projects:
Studies of the macromolecular structure, dynamics and function in solution

Purine nucleoside phosphorylases (PNP): three-dimensional structure and molecular mechanism of catalysis

Translation initiation and intracellular transport: biophysics of protein and mRNA interactions

Role of 5' mRNA and 5' U snRNA cap structures in regulation of gene expression