Prof. Dr hab. Barbara Czochralska

Division of Biophysics
Institute of Experimental Physics
University of Warsaw
Zwirki i Wigury 93, 02-089 Warsaw, Poland

Phone: +48 22 5540779

E-mail: barc@biogeo.uw.edu.pl

Research interests

  1. Electrochemistry and photochemistryof biologically active compounds: nucleic bases and coenzymes.
  2. Molecular photophysics: laser flash photolysis of coenzymes,and nucleosides of chemotherapeutic significance.(antivirus and antileucamic drugs).

Methods

  1. Electrochemistry
  2. Photochemistry
  3. Fluorescence
  4. Laser flash photolysis

Professional experience

1962 Ph.D. Jagiellonian University (Cracow)
1963 - 1974 Assist. Professor, University of Warsaw
1973 - 1974 Post-doctoral stay, Department of Chemistry, University of Michigan, Ann Arbor, USA (Fulbright Fellowship)
1975 and Johns, Hopkins University, Baltimore,USA
1975 Habilitation (Assoc. professor), University of Warsaw
1977, 1979, 1982, 1983 3 - months stays in the Institue of Physical Chemistry, KFA, Julich, Germany
1983 - 2000 several stays as visiting professor in the Institute of Molecular Photophysics, Univerite Paris-Sud, CNRS, Orsay, France (Research cooperation)

Selected publications

  1. B.Czochralska, D.Shugar, S.Arora, R.Bates and R.S.Cutler, Structure,cyclization and other properties of the electrochemical reduction product of 4,6-dimethylpyrimidon-2,: J.Am.Chem.Soc. 99 (1977) 2583.
  2. Badanie mechanizmów elektroredukcji pochodnych zasad nukleinowych (The electroreduction mechanisms of nucleic bases derivatives.) Wydawnictwo Uniwersytetu Warszawskiego. Warszawa 1977
  3. B.Czochralska and L.Lindqvist, Biphotonicoxidation of NADH on laser excitation 353nm, Chem. Phys. Letters 101(1983) 297
  4. B.Czochralska, M.Wrona and D.Shugar, Electrochemically induced, photochemically reversible dimers of pyrimidine and purine, Springer Verlag: Topics in Current Chemistry, 30 (1986) 133-181
  5. B.Czochralska,B.Bojarska, K.Pawlicki and D.Shugar, Photochemical and enzymatic redox transformations of reduced forms of coenzyme NADP+, Photochem. Photobiol. 51(1990) 401
  6. L.Lindqvist, B.Czochralska and W.Kawczyński, Intermediates in the oxidation of a dihydrpyridine derivative of AZT related to AIDS dementia, studied by nanosecond laser photolysis, J.Photochem.Photobiol. B.Biol. 23 (1994) 207-211.
  7. Wrażliwość materii (Sensibility of matter) Wydawnictwo DIG, Warszwa 1998.
  8. B.Czochralska and L.Lindqvist, Reaction mechanism in the photochemistry of the antileuceamic agents 2-chloro and 2-bromo-2'deoxy adenosine, studied by nanosecond laser flash photolysis, J.Photochem. Photobiol. B.Biol. (1999)28-32).
  9. L.Lindqvist, B.Czochralska, M.-P.Fontaine-Aupart, W.Kawczyński, F.Tfibel and T.Douki, Photochemistry of 2-chloropyrimidine, Photochem.Photobiol.Sci.,1 (2002)600-606.