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Warsaw University Faculty of Physics
WERSJA POLSKA  Research    People    Education
Name: dr Joanna Żuberek
Address: Department of Biophysics, Institute of Experimental Physics, Warsaw University,
Zwirki i Wigury 93, 02-089 Warsaw, Poland
Phone: +48 22 55 40 781 lub +48 22 55 40 775
E-mail: jzuberek@biogeo.uw.edu.pl
Research interests:
Molekularne mechanizmy regulacji biosyntezy białka, rola fosforylacji faktora inicjacyjnego eIF4E. Badanie oddziaływań izoform białka eIF4E z różnych organizmów z analogami 5' końca mRNA.
Uzyskiwanie białek rekombinowanych przy użyciu intein.
Selected publications:
  1. Westman B., Beeren L., Grudzien E., Stepinski J., Worch R, Zuberek J., Jemielity J., Stolarski R., Darzynkiewicz E., Rhoads RE., Preiss T. (2005) The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro. RNA, 11: 1505-1513.
  2. Stepinski J., Zuberek J., Jemielity J., Kalek M., Stolarski R., Darzynkiewicz E. Novel dinucleoside 5',5'-triphosphate cap analogues. (2005) Synthesis and affinity for murine translation factor eIF4E. Nucleosides Nucleotides Nucleic Acids, 24: 628-633.
  3. Yoffe Y., Zuberek J., Lewdorowicz M., Zeira Z., Keasar C., Shaanan B., Orr-Dahan I., Jankowska-Anyszka M., Darzynkiewicz E., Shapira M. (2004) Cap binding activity of a eIF4E homologue from Leishmania. RNA, 10: 1764-1775.
  4. Lewdorowicz M., Yoffe Y., Zuberek J., Jemielity J., Stepinski J., Kierzek R., Stolarski R., Shapira M., Darzynkiewicz E. (2004) Chemical synthesis and binding activity of trypanpsomatid cap-4 structure. RNA, 10: 1469-1478.
  5. Zuberek J., Jemielity J., Jablonowska A., Stepinski J., Dadlez M., Stolarski R., Darzynkiewicz E. (2004) Influence of electric charge at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus. Biochemistry, 43: 5370-5379.
  6. Zuberek J., Jemielity J., Niedzwiecka A., Stepinski J., Wyslouch-Cieszynska A., Stolarski R., Darzynkiewicz E. (2003) Influence of the length of the phosphate chain in mRNA 5 ' cap analogues on their interaction with eukaryotic initiation factor 4E. Nucleosides Nucleotides Nucleic Acids, 22: 1707-1710.
  7. Jemielity J., Fowler T., Zuberek J., Stepinski J., Lewdorowicz M., Niedzwiecka A., Stolarski R., Darzynkiewicz E., Rhoads RE. (2003) Novel "anti-reverse" cap analogs with superior translational properties. RNA, 9: 1108-1122.
  8. Zuberek J., Wyslouch-Cieszynska A., NiedĽwiecka A., Dadlez M., Stepinski J., Augustyniak W., Gingras A-C., Zhang Z., Burley S. K., Sonenberg N., Stolarski R., Darzynkiewicz E. (2003) Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion; Intein-Mediated Protein Ligation strategy to obtain phosphorylated protein. RNA, 9: 52-61.
Participation in research projects:
Role of 5' mRNA and 5' U snRNA cap structures in regulation of gene expression