Wybrane publikacje (1997-2007):
- G. Koellner, M. Luić, D.Shugar, W. Saenger and A. Bzowska, Crystal structure of
calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 Ĺ
resolution. J. Mol. Biol. 265, 202-216 (1997).
cytowana 50 razy lub więcej
- G. Koellner, M. Luić, D. Shugar, W. Saenger and A. Bzowska, Crystal structure of the
ternary complex of E. coli purine nucleoside phosphorylase with formycin B, a structural
analogue of the substrate inosine, and phosphate (sulphate) at 2.1 Ĺ resolution.
J. Mol. Biol. 280, 153-166 (1998).
cytowana 40 razy lub więcej
- B. Wielgus-Kutrowska, J. Tebbe, J. Wierzchowski, D. Shugar, W. Saenger, G. Koellner
and A. Bzowska, Binding of substrates by purine nucleoside phosphorylase (PNP) from
Cellulomonas sp. - kinetic and spectrofluorimetric studies. Nucleosides and
Nucleotides 18, 871-872 (1999).
- J. Tebbe, A. Bzowska, B. Wielgus-Kutrowska, W. Schröder, Z. Kazimierczuk, D. Shugar,
W. Saenger, W. and G. Koellner, Crystal structures of purine nucleoside phosphorylase
(PNP) from Cellulomonas sp. and its implications of the molecular mechanism of trimeric
PNPs. J. Mol. Biol. 294, 1239-1255 (1999).
cytowana 30 razy lub więcej
- A. Bzowska, E. Kulikowska, and D. Shugar, Purine nucleoside phosphorylase:
properties, functions and clinical aspects. Pharmacology & Therapeutics 88, 349-425 (2000).
cytowana 100 razy lub więcej
- M. Luić, G. Koellner, D. Shugar, W. Saenger and A. Bzowska, Calf spleen purine
nucleoside phosphorylase: structure of its ternary complex with an N(7)-acycloguanosine
inhibitor and a phosphate anion. Acta Cryst. D57, 30-36 (2001).
- G. Koellner, A. Bzowska, B. Wielgus-Kutrowska, M. Luić, T. Steiner, W. Saenger and
J. Stępiński, Open and closed conformation of the E. coli purine nucleoside phosphorylase
active center and implications for the catalytic mechanism. J. Mol. Biol. 315, 351-371
(2002).
- A. Bzowska, Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism,
hydrolysis of 7-methylguanosine, and oligomeric state in solution. Biochim. Biophys.
Acta 1596, 293-317 (2002).
- B. Wielgus-Kutrowska, A. Bzowska, J. Tebbe, G. Koellner and D. Shugar,
Purine nucleoside phosphorylase from Cellulomonas sp.: physicochemical properties and
binding of substrates determined by ligand-dependent enhancement of enzyme intrinsic
fluorescence, and by protective effects of ligands on thermal inactivation of the enzyme.
Biochim. Biophys. Acta 1597, 320-334 (2002).
- B. Wielgus-Kutrowska, A. Holy, J. Frank, G. Koellner and A. Bzowska, Interactions
of trimeric purine nucleoside phosphorylases with ground state analogues - calorimetric
and fluorimetric studies. Nucleosides, Nucleotides and Nucleic Acids 22, 1695-1698 (2003).
- A. Bzowska, G. Koellner, B. Wielgus-Kutrowska, A. Stroh, G. Raszewski, A. Holý,
T. Steiner, J. Frank, Crystal structure of calf spleen purine nucleoside phosphorylase
with two full trimers in the asymmetric unit: important implications for the mechanism
of catalysis. J. Mol. Biol. 342, 1015-1032 (2004).
- M. Luić, G. Koellner, T. Yokomatsu, S. Shibuya and A. Bzowska, Calf spleen
purine-nucleoside phosphorylase: crystal structure of the binary complex with a potent
multisubstrate analogue inhibitor. Acta. Cryst. D 60, 1417-1424 (2004).
- J. Wierzchowski, A. Bzowska, K. Stępniak, D. Shugar, Interactions of calf spleen
purine nucleoside phosphorylase with 8-azaguanine, and a bisubstrate analogue inhibitor:
implications for the reaction mechanism. Z. Naturforsch. 59c, 713-725 (2004).
- B. Wielgus-Kutrowska, A. Bzowska, Kinetic properties of Cellulomonas sp.
purine nucleoside phosphorylase with typical and non-typical substrates: implications
for the reaction mechanism. Nucleosides, Nucleotides and Nucleic Acids 5-7, 471-476 (2005).
- K. Banach, E. Bojarska, Z. Kazimierczuk, L. Magnowska, A. Bzowska, Kinetic model
of oxidation catalyzed by xanthine oxidase - the final enzyme in degradation of purine
nucleosides and nucleotides. Nucleosides, Nucleotides and Nucleic Acids 5-7, 465-469 (2005).
- M. Długosz, A. Bzowska, J, Antosiewicz, Stopped-flow studies of guanine binding
by calf spleen purine nucleoside phoshorylase. Biophys. Chem. 115, 67-76 (2005).
- J. Behlke, G. Koellner, A Bzowska, Oligomeric structure of mammalian purine nucleoside
phosphorylase in solution determined by analytical ultracentrifugation. Z. Naturforsch.
60c (2005).
- B. Wielgus-Kutrowska, A. Bzowska, Probing the mechanism of purine nucleoside phosphorylase by steady-state
kinetic studies and ligand binding characterization determined by fluorimetric titrations.
Biochim. Biophys. Acta 1764, 887-902 (2006).
- A. Modrak-Wójcik, K. Stepniak, V. Akoev, M. Żółkiewski, A. Bzowska, Molecular architecture of E. coli purine
nucleoside phosphorylase studied by analytical ultracentrifugation and CD-spectroscopy.
Prot. Sci. 15, 1794-1800 (2006).
- B. Wielgus-Kutrowska, J. Antosiewicz, M. Długosz, A. Holý, A. Bzowska, Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow
studies of binding of multisubstrate analogue inhibitor -
2-amino-9-[2-(phosphonomethoxy)-ethyl]-6-sulfanylpurine. Biophys. Chem. 125, 260-268 (2007).
- B. Wielgus-Kutrowska, M. Narczyk. A. Buszko, A. Bzowska, P. Clark, Folding and
unfolding of non-fluorescent mutant of green fluorescent protein.
J. Phys.: Condens. Matter 19, 285223 (2007).
- A. Modrak-Wójcik, K. Stepniak, B. Kierdaszuk, A. Bzowska,
Is purine nucleoside phosphorylase an example of a morpheein?
J. Phys.: Condens. Matter, 19, 285219 (2007).
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